Cookies are used for analytics and marketing. Enable JavaScript to manage preferences, or see our Privacy Policy.

Abstracts Mathematics

Add abstract

Want to add your dissertation abstract to this database? It only takes a minute!

Search abstract

Search for abstracts by subject, author or institution

Share this abstract

dissertation.com
on Facebook

Modelling the interaction of influenza virus and its antibody

by Shilian Xu

Institution:	Monash University
Department:	Medicine, Nursing and Health Sciences
Degree:
Year:	2022
Keywords:	Microbiology; Immunology; Virology; Biological Mathematics; antibody neutralisation; influenza virus; bistable viral kinetics; antisera dependent enhancement; mathematical model; simulation estimation; focus reduction assay; homologous antisera; genetic d
Posted:	3/25/2025
Record ID:	2289879
Full text PDF:	http://hdl.handle.net/10.26180/19380371.v1

Abstract

The influenza virus is a major human health concern. Pre-existing antibody-mediated immunity provide an irreplaceable role in the clearance of influenza virus via multiple mechanisms. Protection against influenza infection can be diminished by a diverse set of neutralisation escape mechanisms and by host exposure history. This study applied mathematical models to experimental data to explain how antibody concentration, viral inoculum size, and antisera-dependent enhancement determine influenza virus infectivity in the respiratory epithelium. This work proposed that antibody-induced bistable viral kinetics and antisera dependent enhancement was responsible for observed influenza A reinfection and vaccine-associated enhanced disease.